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Indigo

Total Synthesis Of Natural Products With Antimicrobial Activity by Andrew Giltrap, Hardcover | Indigo Chapters

From Andrew Giltrap

Current price: $204.50
Total Synthesis Of Natural Products With Antimicrobial Activity by Andrew Giltrap, Hardcover | Indigo Chapters
Total Synthesis Of Natural Products With Antimicrobial Activity by Andrew Giltrap, Hardcover | Indigo Chapters

Indigo

Total Synthesis Of Natural Products With Antimicrobial Activity by Andrew Giltrap, Hardcover | Indigo Chapters

From Andrew Giltrap

Current price: $204.50
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Size: 1 x 9.25 x 1.34

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This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of thePseudomonas aeruginosabiofilms that are responsible for significant mortality among cystic fibrosis patients. | Total Synthesis Of Natural Products With Antimicrobial Activity by Andrew Giltrap, Hardcover | Indigo Chapters

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