Volume 95 ofInternational Review of Neurobiologyfocuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use. Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitorsPreclinical models in COMT inhibitor devlopmentTransgenic COMT mice latest information summarizedChemistry of COMT inhibitors and their design with molecular modellingCOMT gene and its regulation and relation to dopamine related diseasesRole of cofactor SAM regulation in relation to homocysteineNonclinical and clinical safety of COMT inhibitors summarizedFuture prospects of COMT inhibitors in Parkinson's disease | Basic aspects of Catechol-O-methyltransferase and the clinical applications of its inhibitors by Erkki Nissinen, Hardcover | Indigo Chapters